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Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice

Abstract : Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced MetS. Seed meals from two Camelina sativa lines enriched, respectively, in C24-and C16-NH 2 − glycosyl-inositol-phosphoryl-ceramides (NH 2 GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH 2 GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH 2 GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels. Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length.
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https://hal-agroparistech.archives-ouvertes.fr/hal-02463037
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Submitted on : Thursday, October 21, 2021 - 9:43:20 AM
Last modification on : Wednesday, October 27, 2021 - 6:15:01 AM

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Dominique Hermier, Annaig Lan, Fredeŕique Tellier, Anne Blais, Marta Culetto, et al.. Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice. Journal of Agricultural and Food Chemistry, American Chemical Society, 2020, 68 (3), pp.788-798. ⟨10.1021/acs.jafc.9b06829⟩. ⟨hal-02463037⟩

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