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Journal articles
Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice
Abstract : Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced MetS. Seed meals from two Camelina sativa lines enriched, respectively, in C24-and C16-NH 2 − glycosyl-inositol-phosphoryl-ceramides (NH 2 GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH 2 GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH 2 GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels. Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length.
https://hal-agroparistech.archives-ouvertes.fr/hal-02463037
Contributor : Jean-Denis Faure <>
Submitted on : Monday, December 21, 2020 - 3:07:16 PM
Last modification on : Tuesday, March 2, 2021 - 4:04:01 PM
Contributor : Jean-Denis Faure <>
Submitted on : Monday, December 21, 2020 - 3:07:16 PM
Last modification on : Tuesday, March 2, 2021 - 4:04:01 PM