Urinary Medium - Chained Acyl - Carnitines Sign High Caloric Intake whereas Short - Chained Acyl-Carnitines Sign High - Protein Diet within a High-Fat, Hypercaloric Diet in a Randomized Crossover Design Dietary Trial - Archive ouverte HAL Access content directly
Journal Articles Nutrients Year : 2021

Urinary Medium - Chained Acyl - Carnitines Sign High Caloric Intake whereas Short - Chained Acyl-Carnitines Sign High - Protein Diet within a High-Fat, Hypercaloric Diet in a Randomized Crossover Design Dietary Trial

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Abstract

The western dietary pattern is known for its frequent meals rich in saturated fat and protein, resulting in a postprandial state for a large part of the day. Therefore, our aim was to investigate the postprandial glucose and lipid metabolism in response to high (HP) or normal (NP) protein, high-fat hypercaloric diet and to identify early biomarkers of protein intake and hepatic lipid accumulation. In a crossover design, 17 healthy subjects were randomly assigned to consume a HP or NP hypercaloric diet for two weeks. In parallel, a control group (CD; n = 10) consumed a weight-maintaining control diet. Biomarkers of postprandial lipid and glucose metabolism were measured in 24 h urine and in plasma before and following a meal challenge. The metabolic profile of urine but not plasma, showed increased excretion of 13 C, carnitine and short chain acyl-carnitines after adaptation to the HP diet. Urinary excretion of decatrienoylcarnitine and octenoylcarnitine increased after adaptation to the NP diet. Our results suggest that the higher excretion of short-chain urinary acyl-carnitines could facilitate the elimination of excess fat of the HP diet and thereby reduce hepatic fat accumulation previously reported, whereas the higher excretion medium-chains acyl-carnitine could be early biomarkers of hepatic lipid accumulation.
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hal-03882412 , version 1 (02-12-2022)

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Nadezda N. Khodorova, Annemarie Rietman, Douglas N Rutledge, Jessica Schwarz, Julien Piedcoq, et al.. Urinary Medium - Chained Acyl - Carnitines Sign High Caloric Intake whereas Short - Chained Acyl-Carnitines Sign High - Protein Diet within a High-Fat, Hypercaloric Diet in a Randomized Crossover Design Dietary Trial. Nutrients, 2021, 13 (4), pp.1191. ⟨10.3390/nu13041191⟩. ⟨hal-03882412⟩
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