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Journal articles
Organic solvent- and catalyst-free Baeyer–Villiger oxidation of levoglucosenone and dihydrolevoglucosenone (Cyrene®): a sustainable route to ( S )-γ-hydroxymethyl-α,β-butenolide and ( S )-γ-hydroxymethyl-γ-butyrolactone
Abstract : A straightforward and sustainable route to (S)-γ-hydroxymethyl-α,β-butenolide (HBO) and (S)-γ-hydroxymethyl-α,β-butyrolactone (2H-HBO), two valuable chemical platforms for the synthesis of fine chemicals such as drugs, pheromones, flavors and fragrances, has been optimized using renewable cellulose-based levoglucosenone (LGO) and Cyrene® as starting materials and aqueous H2O2 as both a solvent and an oxidizing agent. Combined with short-path distillation, this procedure provides enantiopure HBO and 2H-HBO in yield as high as 72% at the kilo scale.
https://hal-agroparistech.archives-ouvertes.fr/hal-03473084
Contributor : Amandine Flourat Connect in order to contact the contributor
Submitted on : Thursday, December 9, 2021 - 4:50:33 PM
Last modification on : Tuesday, December 14, 2021 - 11:27:10 AM
Contributor : Amandine Flourat Connect in order to contact the contributor
Submitted on : Thursday, December 9, 2021 - 4:50:33 PM
Last modification on : Tuesday, December 14, 2021 - 11:27:10 AM