Skip to Main content Skip to Navigation
Journal articles

Short Chain Fatty Acids – mechanisms and functional importance in the gut

Abstract : In recent years, the importance of the gut microbiota in human health has been revealed and many publications have highlighted its role as a key component of human physiology. Owing to the use of modern sequencing approaches, the characterisation of the microbiome in healthy individuals and in disease has demonstrated a disturbance of the microbiota, or dysbiosis, associated with pathological conditions. The microbiota establishes a symbiotic crosstalk with their host: commensal microbes benefit from the nutrient-rich environment provided by the gut and the microbiota produces hundreds of proteins and metabolites that modulate key functions of the host, including nutrient processing, maintenance of energy homoeostasis and immune system development. Many bacteria-derived metabolites originate from dietary sources. Among them, an important role has been attributed to the metabolites derived from the bacterial fermentation of dietary fibres, namely SCFA linking host nutrition to intestinal homoeostasis maintenance. SCFA are important fuels for intestinal epithelial cells (IEC) and regulate IEC functions through different mechanisms to modulate their proliferation, differentiation as well as functions of subpopulations such as enteroendocrine cells, to impact gut motility and to strengthen the gut barrier functions as well as host metabolism. Recent findings show that SCFA, and in particular butyrate, also have important intestinal and immuno-modulatory functions. In this review, we discuss the mechanisms and the impact of SCFA on gut functions and host immunity and consequently on human health.
Keywords : SCFA microbiota gut 14
Complete list of metadatas

Cited literature [136 references]  Display  Hide  Download

https://hal-agroparistech.archives-ouvertes.fr/hal-02536149
Contributor : Pierre Larraufie <>
Submitted on : Thursday, June 18, 2020 - 7:06:59 PM
Last modification on : Wednesday, October 14, 2020 - 4:21:43 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2020-12-18

Please log in to resquest access to the document

Identifiers

Collections

Citation

Camille Martin-Gallausiaux, Ludovica Marinelli, Herve Blottiere, Pierre Larraufie, Nicolas Lapaque. Short Chain Fatty Acids – mechanisms and functional importance in the gut. Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2020, pp.1-13. ⟨10.1017/S0029665120006916⟩. ⟨hal-02536149⟩

Share

Metrics

Record views

90