Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

Louis Mouterde (1) , Florent Allais (1)

1 ABI - Agro-Biotechnologies Industrielles

The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized-by using a combination of a Design of Experiment and a standard optimization approach-a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86-99% and in 85-97% yields.

Keywords: Caffeic acid; Sinapic acid; ferulic acid; Knoevenagel-Doebner; microwaves; Coumaric acid; p-hydroxycinnamic acids

Domains: Organic chemistry

Louis Mouterde, Florent Allais. Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis. Frontiers in Chemistry, 2018, 6, pp.426. ⟨10.3389/fchem.2018.00426⟩. ⟨hal-02527502⟩