Skip to Main content Skip to Navigation
Journal articles

Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

Abstract : The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized-by using a combination of a Design of Experiment and a standard optimization approach-a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86-99% and in 85-97% yields.
Document type :
Journal articles
Complete list of metadatas

Cited literature [47 references]  Display  Hide  Download

https://hal-agroparistech.archives-ouvertes.fr/hal-02527502
Contributor : Louis Mouterde <>
Submitted on : Wednesday, April 1, 2020 - 11:21:58 AM
Last modification on : Monday, April 6, 2020 - 3:27:25 PM

File

2018-09 FChem.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Louis Mouterde, Florent Allais. Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis. Frontiers in Chemistry, Frontiers, 2018, 6, pp.426. ⟨10.3389/fchem.2018.00426⟩. ⟨hal-02527502⟩

Share

Metrics

Record views

63

Files downloads

50