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AMP-activated protein kinase and hepatic genes involved in glucose metabolism.

Abstract : Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
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Contributor : Dalila Azzout-Marniche Connect in order to contact the contributor
Submitted on : Thursday, October 5, 2017 - 8:26:53 PM
Last modification on : Wednesday, September 28, 2022 - 4:20:11 PM


  • HAL Id : hal-01611450, version 1
  • PUBMED : 12546689


P Ferré, Dalila D. Azzout-Marniche, F. Foufelle. AMP-activated protein kinase and hepatic genes involved in glucose metabolism.. Biochemical Society Transactions, Portland Press, 2003, pp.220-3. ⟨hal-01611450⟩



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