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Abstract : Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
Type de document :
Article dans une revue
Biochemical Society Transactions, Portland Press, 2003, pp.220-3. 〈10.1042/〉
https://hal-agroparistech.archives-ouvertes.fr/hal-01611450
Contributeur : Dalila Azzout-Marniche
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Soumis le : jeudi 5 octobre 2017 - 20:26:53
Dernière modification le : vendredi 4 janvier 2019 - 17:33:33
P Ferré, Dalila Azzout-Marniche, F. Foufelle. AMP-activated protein kinase and hepatic genes involved in glucose metabolism.. Biochemical Society Transactions, Portland Press, 2003, pp.220-3. 〈10.1042/〉. 〈hal-01611450〉
