AMP-activated protein kinase and hepatic genes involved in glucose metabolism. - Archive ouverte HAL Access content directly
Journal Articles Biochemical Society Transactions Year : 2003

AMP-activated protein kinase and hepatic genes involved in glucose metabolism.

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Abstract

Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
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Dates and versions

hal-01611450 , version 1 (05-10-2017)

Identifiers

  • HAL Id : hal-01611450 , version 1
  • PUBMED : 12546689

Cite

P Ferré, Dalila D. Azzout-Marniche, F. Foufelle. AMP-activated protein kinase and hepatic genes involved in glucose metabolism.. Biochemical Society Transactions, 2003, pp.220-3. ⟨hal-01611450⟩
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