AgroParisTech (16 rue Claude Bernard F-75231 Paris Cedex 05 - France)
Abstract : Mammalian AMP-activated protein kinase presents strong structural and functional similarities with the yeast sucrose non-fermenting 1 (Snf1) kinase involved in the derepression of glucose-repressed genes. It is now clearly established that AMP-activated protein kinase in the liver decreases glycolytic/lipogenic gene expression as well as genes involved in hepatic glucose production. This is achieved through a decreased transcriptional efficiency of transcription factors such as sterol-regulatory-element-binding protein-1c, carbohydrate-response-element-binding protein, hepatocyte nuclear factor 4 alpha or forkhead-related protein. Clearly, the long-term consequences of AMP-activated protein kinase activation have to be taken into account if activators of this enzyme are to be designed as anti-diabetic drugs.
https://hal-agroparistech.archives-ouvertes.fr/hal-01611450
Contributor : Dalila Azzout-Marniche
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Submitted on : Thursday, October 5, 2017 - 8:26:53 PM
Last modification on : Saturday, April 20, 2019 - 2:04:17 AM
P Ferré, Dalila Azzout-Marniche, F. Foufelle. AMP-activated protein kinase and hepatic genes involved in glucose metabolism.. Biochemical Society Transactions, Portland Press, 2003, pp.220-3. ⟨10.1042/⟩. ⟨hal-01611450⟩
