Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein - Archive ouverte HAL Access content directly
Journal Articles Microbial Pathogenesis Year : 1991

Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein

(1, 2) , (1, 2) , (1, 2) , (1, 2)
1
2

Abstract

The class 4 protein of Neisseria meningitidis is a highly conserved outer membrane protein, closely related to the protein PIII of Neisseria gonorrhoea. Monoclonal antibodies SM50 and SM54 raised against PIII also react with class 4 protein but do not promote complement mediated bactericidal killing of meningococci. In addition, mAb SM50 inhibits the anti-meningococcal bactericidal activity both of normal human sera and of mAb SM300, directed against a protective epitope on the class 1 outer membrane protein. The ability of class 4 protein to induce such 'blocking' antibodies suggests that its presence in experimental vaccines, based on meningococcal outer membranes, may be antagonistic to the development of effective bactericidal immunity.
Not file

Dates and versions

hal-03665504 , version 1 (11-05-2022)

Identifiers

Cite

Colin R. Tinsley, A. Munkley, M. Virji, J.E. Heckels. Blocking of bactericidal killing of Neisseria meningitidis by antibodies directed against class 4 outer membrane protein. Microbial Pathogenesis, 1991, 11 (6), p. 447-452. ⟨10.1016/0882-4010(91)90041-8⟩. ⟨hal-03665504⟩
5 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More