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Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence

Abstract : The distribution of the haemoglobin receptor gene (hmbR) was investigated in disease and carried Neisseria meningitidis isolates revealing that the gene occurred at a significantly higher frequency in disease isolates compared to those obtained from carriage. Where hmbR was absent, the locus was occupied by the cassettes exl2 or exl3, or with a "pseudo hmbR" gene designated exl4. The hmbR locus in published N. meningitidis genomes, as well as N. gonorrhoeae and N. lactamica ST-640, exhibited characteristics of a pathogenicity island. These data are consistent with a role for the hmbR gene in meningococcal disease.
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https://hal-agroparistech.archives-ouvertes.fr/hal-03665200
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Odile Harrison, Nicholas Evans, Jessica Blair, Holly Grimes, Colin R. Tinsley, et al.. Epidemiological Evidence for the Role of the Hemoglobin Receptor, HmbR, in Meningococcal Virulence. Journal of Infectious Diseases, Oxford University Press (OUP), 2009, 200 (1), p.98. ⟨10.1086/599377⟩. ⟨hal-03665200⟩

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