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Predictive modeling and experimental implementation of organic acids in stream recovery by reactive extraction in membrane contactors

Abstract : Membrane-based reactive extraction as an in situ product recovery technique is a promising strategy for process intensification, in particular in the case of the bioproduction of organic acids. Reactive extraction allows a high selectivity for the extraction of the targeted acid and the microporous membrane keeps biocatalysts in the aqueous broth while implementing a large liquid–liquid surface area and ensuring a dispersion-free contact, without problems of emulsion formation. This paper deals specifically with the extraction of biobased 3-hydroxypropionic acid using tri-n-octylamine in n-decanol. In order to maintain an effective driving force for 3-HP transfer into the organic phase, this latter was continuously regenerated by recovering the acid in a back-extraction aqueous phase, giving a complete pertraction process. A mass transfer model for this process was developed. It is based on the boundary layer theory and takes into account chemical and physical equilibria of complexation/dissociation and partitioning, species diffusion in the membrane pores and viscosity variations in the organic phase. Viscosity highly depends on acid concentration, increasing up to 50% when 3-HP concentration reaches 28 g.L-1. Thus, it was possible to predict different experimental results with R2 ≥ 0.99, totally neglecting chemical kinetics and interfacial resistance for both extraction and back-extraction steps. The model allows the prediction of extraction kinetics with (1) fixed initial concentrations and (2) with gradual 3-HP feed (mimicking a bioconversion) in transient and steady states coupled with back-extraction (globally also called pertraction). Model based analysis of mass transfer mechanisms led to the construction of a nomogram giving 3-HP stationary concentration in the case of a typical production rate, enabling for example a rapid organic phase selection or membrane sizing.
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Submitted on : Tuesday, February 1, 2022 - 5:27:47 PM
Last modification on : Friday, August 5, 2022 - 2:41:13 PM
Long-term archiving on: : Tuesday, May 3, 2022 - 8:46:03 AM


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F. Chemarin, V. Athès, W. Buquet, M. Bedu, F. Allais, et al.. Predictive modeling and experimental implementation of organic acids in stream recovery by reactive extraction in membrane contactors. Chemical Engineering Journal, 2022, 431 (part 2), pp.134067. ⟨10.1016/j.cej.2021.134067⟩. ⟨hal-03516921⟩



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