Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim

Hery Mitsutake (1) , Marina de Géa Neves (1) , Douglas N Rutledge (2, 3) , Ronei Jesus Poppi (1) , Márcia Cristina Breitkreitz (1)

1 UNICAMP - Instituto de Quimica
2 SayFood - Paris-Saclay Food and Bioproduct Engineering
3 Charles Sturt University [Australia]

Solid dispersions are an interesting option to improve the solubility of Class II (high permeability, low water solubility) drugs of the Biopharmaceutical Classification System without the use of organic solvents. However, structural changes (polymorphism) may be present in both active pharmaceutical ingredients (API) and excipients, which require evaluation during pharmaceutical

Domains: Analytical chemistry; Medication

Hery Mitsutake, Marina de Géa Neves, Douglas N Rutledge, Ronei Jesus Poppi, Márcia Cristina Breitkreitz. Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim. Journal of Chemometrics, 2020, ⟨10.1002/cem.3288⟩. ⟨hal-03040604⟩