Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim - Archive ouverte HAL Access content directly
Journal Articles Journal of Chemometrics Year : 2020

Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim

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Abstract

Solid dispersions are an interesting option to improve the solubility of Class II (high permeability, low water solubility) drugs of the Biopharmaceutical Classification System without the use of organic solvents. However, structural changes (polymorphism) may be present in both active pharmaceutical ingredients (API) and excipients, which require evaluation during pharmaceutical
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hal-03040604 , version 1 (18-12-2020)

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Hery Mitsutake, Marina de Géa Neves, Douglas N Rutledge, Ronei Jesus Poppi, Márcia Cristina Breitkreitz. Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim. Journal of Chemometrics, 2020, ⟨10.1002/cem.3288⟩. ⟨hal-03040604⟩
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