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Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim

Abstract : Solid dispersions are an interesting option to improve the solubility of Class II (high permeability, low water solubility) drugs of the Biopharmaceutical Classification System without the use of organic solvents. However, structural changes (polymorphism) may be present in both active pharmaceutical ingredients (API) and excipients, which require evaluation during pharmaceutical
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https://hal-agroparistech.archives-ouvertes.fr/hal-03040604
Contributor : Douglas Rutledge <>
Submitted on : Friday, December 18, 2020 - 1:41:17 PM
Last modification on : Tuesday, June 15, 2021 - 2:57:32 PM

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Hery Mitsutake, Marina Neves, Douglas Rutledge, Ronei Poppi, Márcia Breitkreitz. Extraction of information about structural changes in a semisolid pharmaceutical formulation from near‐infrared and Raman images by multivariate curve resolution–alternating least squares and ComDim. Journal of Chemometrics, Wiley, 2020, ⟨10.1002/cem.3288⟩. ⟨hal-03040604⟩

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