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Determinants of amino acid bioavailability from ingested protein in relation to gut health

Abstract : Purpose of review: The current review provides an update on the recent research developments regarding amino acid bioavailability in conditions of both good health and gut disorders. Recent findings: Determination of amino acid bioavailability is complex and invasive. Minimally invasive methods using stable isotopes have been developed for humans. Data were collected in different models - humans, pigs and rats with various procedures - leading to interstudy variability. They mainly focused on either plant protein or the effect of food processing on animal protein. Plant protein in their original food matrix (legumes, grains, nuts) are generally less digestible (about 80%) than animal protein (meat, egg, milk; about 93%). Food processing has a limited impact on animal protein but its effect might be higher on plant protein. Few studies have documented the effect of gut disorders on protein digestibility, except in gastric bypass where paradoxical effects were reported. Data are needed to identify the amplitude of protein malabsorption in diseases such as inflammatory bowel disease or environmental enteric dysfunction. Summary: The past 5 years have seen a renewed interest in amino acid bioavailability in view of assessing protein quality to support current shifts in protein sourcing. Methodological developments have been performed and several studies have reported values in various models. The question of protein digestibility in gut disorders remains poorly addressed.
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https://hal-agroparistech.archives-ouvertes.fr/hal-03010437
Contributor : Claire Gaudichon <>
Submitted on : Tuesday, November 17, 2020 - 5:06:13 PM
Last modification on : Friday, November 27, 2020 - 10:14:10 AM

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Claire Gaudichon, Juliane Calvez. Determinants of amino acid bioavailability from ingested protein in relation to gut health. Current Opinion in Clinical Nutrition and Metabolic Care, Lippincott, Williams & Wilkins, 2020, Publish Ahead of Print, ⟨10.1097/MCO.0000000000000708⟩. ⟨hal-03010437⟩

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