Importance of the major histocompatibility complex (Swine Leukocyte Antigen) in swine health and biomedical Research

Abstract : In pigs, the major histocompatibility complex (MHC), or swine leukocyte antigen (SLA) complex, maps to Sus scrofa chromosome 7. It consists of three regions, the class I and class III regions mapping to 7p1.1 and the class II region mapping to 7q1.1. The swine MHC is divided by the centromere, which is unique among mammals studied to date. The SLA complex spans between 2.4 and 2.7 Mb, depending on haplotype, and encodes approximately 150 loci, with at least 120 genes predicted to be functional. Here we update the whole SLA complex based on the Sscrofa11.1 build and annotate the organization for all recognized SLA genes and their allelic sequences. We present SLA nomenclature and typing methods and discuss the expression of SLA proteins, as well as their role in antigen presentation and immune, disease, and vaccine responses. Finally, we explore the role of SLA genes in transplantation and xenotransplantation and their importance in swine biomedical models.
Document type :
Journal articles
Complete list of metadatas

Cited literature [142 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02437591
Contributor : Archive Ouverte Prodinra <>
Submitted on : Monday, January 13, 2020 - 8:09:24 PM
Last modification on : Thursday, February 20, 2020 - 7:22:22 PM

Files

Hammer_fulltext.pdf
Explicit agreement for this submission

Identifiers

Citation

Sabine E. Hammer, Chak-Sum Ho, Asako Ando, Claire Rogel Gaillard, Mathieu Charles, et al.. Importance of the major histocompatibility complex (Swine Leukocyte Antigen) in swine health and biomedical Research. Annual Review of Animal Biosciences, Annual Reviews, 2020, 8 (1), pp.1-28. ⟨10.1146/annurev-animal-020518-115014⟩. ⟨hal-02437591⟩

Share

Metrics

Record views

31

Files downloads

22