METHOD FOR TRANSFORMING LEVOGLUCOSENONE INTO 4-HYDROXYMETHYN BUTYROLACTONE OR 4-HYDROXYMETHYL BUTENOLIDE

PROCEDE DE TRANSFORMATION DE LEVOGULCOSENONE EN 4-HYDROXYMETHYLBUTYROLACTONE OU 4-HYDROXYMETHYLBUTENOLIDE

Florent Allais (1, 2) , Amandine Flourat (1, 2) , Aurélien Peru (1, 2) , Andreia Teixeira (1, 2) , Fanny Brunissen (1, 2) , Henri-Eric Spinnler (3, 2)

1 ABI - Agro-Biotechnologies Industrielles
2 AgroParisTech
3 GMPA - Génie et Microbiologie des Procédés Alimentaires

The disclosure relates to a method for transforming levoglucosenone into 4-hydroxymethyl butyrolactone or 4-hydroxymethyl butenolide, comprising a step involving the oxidation of the levoglucosenone, or dihydrolevoglucosenone obtained by hydrogenation of levoglucosenone, by bringing a solution of levoglucosenone or dihydrolevoglucosenone in a solvent into contact with a lipase in the presence of an oxidizing agent and an acyl donor compound. The oxidation step is followed by a step involving the hydrolysis of the reaction mixture obtained and, if necessary, a step involving the hydrogenation of the compound obtained at the end of the hydrolysis step.

Domains: Chemical Sciences

Florent Allais, Amandine Flourat, Aurélien Peru, Andreia Teixeira, Fanny Brunissen, et al.. METHOD FOR TRANSFORMING LEVOGLUCOSENONE INTO 4-HYDROXYMETHYN BUTYROLACTONE OR 4-HYDROXYMETHYL BUTENOLIDE . France, Patent n° : FR20140053957 20140430 / WO2015EP59323 20150429. 2014. ⟨hal-01787823⟩