HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance

Abstract : Diets that promote oxidative stress favor impairment in glucose homeostasis. In this context, increasing the cysteine intake may be beneficial by maintaining glutathione status. We have investigated the effects of dietary cysteine on oxidative stress and glucose homeostasis in rats fed a high-sucrose (HS) diet. Rats were assigned for 6 weeks to a standard diet or to HS diets in which the protein source was either an alpha-lactalbumin-rich whey concentrate (a cysteine-rich protein) or the total milk proteins alone or supplemented with 5.8 or 20 g N-acetylcysteine per kilogram of food. Increasing the cysteine intake prevented HS-induced oxidative stress, as assessed by blood and tissue glutathione and carbonyl levels. At the same time, the HS-induced glucose intolerance, impaired postprandial glycemic control, and decrease in muscle and liver insulin-induced activation of insulin receptor substrate 1 and Akt were prevented by increasing the level of dietary cysteine, a major original finding. Of great interest was the observation that all beneficial effects of cysteine supplementation were duplicated by the consumption of a cysteine-rich protein. These data show that increasing the cysteine intake limits HS-induced impairment of glucose homeostasis and suggest that these effects are mediated by a reduction in oxidative stress.
Complete list of metadata

Contributor : Dalila Azzout-Marniche Connect in order to contact the contributor
Submitted on : Thursday, October 5, 2017 - 8:22:09 PM
Last modification on : Friday, January 28, 2022 - 11:42:04 AM

Links full text




Clémence Blouet, François Mariotti, Dalila Azzout-Marniche, Véronique Mathe, Takashi Mikogami, et al.. Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Radical Biology and Medicine, Elsevier, 2007, 42 (7), pp.1089 - 1097. ⟨10.1016/j.freeradbiomed.2007.01.006⟩. ⟨hal-01611432⟩



Record views