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Journal articles
An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria
Abstract : Among existing dehydration methods, freeze-drying has unique benefits for the stabilization and preservation of biological activity of pharmaceutical products but remains an expensive and time-consuming process. A user-friendly software tool was developed, allowing for interactive selection of process operating condition profiles in order to maximize process productivity while insuring product quality preservation. The software is based on a dynamic, one-dimensional heat and mass transfer model, which can accurately represent both the primary and secondary drying stages and the gradual transition between them. The model was validated in a wide range of operating conditions: − 25 to + 25°C shelf temperature and 10 to 34 Pa total pressure. By comparing a reference sucrose solution with a formulated pharmaceutical product containing polyvinylpyrrolidone (PVP), it is shown that controlling product properties such as glass transition temperature and sorption isotherm can reduce the minimum achievable cycle duration by 12 h (33%).
Cited literature [12 references]
https://hal-agroparistech.archives-ouvertes.fr/hal-01537101
Contributor : Ioan-Cristian Trelea <>
Submitted on : Wednesday, June 14, 2017 - 9:08:45 AM
Last modification on : Saturday, June 27, 2020 - 7:44:07 PM
Long-term archiving on: : Tuesday, December 12, 2017 - 10:49:29 AM
Contributor : Ioan-Cristian Trelea <>
Submitted on : Wednesday, June 14, 2017 - 9:08:45 AM
Last modification on : Saturday, June 27, 2020 - 7:44:07 PM
Long-term archiving on: : Tuesday, December 12, 2017 - 10:49:29 AM
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