An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

Ioan-Cristian Trelea 1 Stéphanie Passot 1 Fernanda Fonseca 1 Michele Marin 1
1 GMPA - Génie et Microbiologie des Procédés Alimentaires
Abstract : Among existing dehydration methods, freeze-drying has unique benefits for the stabilization and preservation of biological activity of pharmaceutical products but remains an expensive and time-consuming process. A user-friendly software tool was developed, allowing for interactive selection of process operating condition profiles in order to maximize process productivity while insuring product quality preservation. The software is based on a dynamic, one-dimensional heat and mass transfer model, which can accurately represent both the primary and secondary drying stages and the gradual transition between them. The model was validated in a wide range of operating conditions: − 25 to + 25°C shelf temperature and 10 to 34 Pa total pressure. By comparing a reference sucrose solution with a formulated pharmaceutical product containing polyvinylpyrrolidone (PVP), it is shown that controlling product properties such as glass transition temperature and sorption isotherm can reduce the minimum achievable cycle duration by 12 h (33%).
Keywords : Glass transition temperature Dynamic modeling Lyophilization Optimization
Type de document :
Article dans une revue
Drying Technology, Taylor & Francis, 2007, 25 (5), pp.741-751. 〈10.1080/07373930701370100〉
Liste complète des métadonnées

Littérature citée [12 références]  Voir  Masquer  Télécharger
https://hal-agroparistech.archives-ouvertes.fr/hal-01537101
Contributeur : Ioan-Cristian Trelea <>
Soumis le : mercredi 14 juin 2017 - 09:08:45
Dernière modification le : jeudi 15 juin 2017 - 01:11:01
Document(s) archivé(s) le : mardi 12 décembre 2017 - 10:49:29

Fichier

Postprint Trelea Passot 2007 D...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

AGROPARISTECH | INRA

Citation

Ioan-Cristian Trelea, Stéphanie Passot, Fernanda Fonseca, Michele Marin. An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria. Drying Technology, Taylor & Francis, 2007, 25 (5), pp.741-751. 〈10.1080/07373930701370100〉. 〈hal-01537101〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

117

Téléchargements de fichiers

182

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD