M. Abadias, A. Benabarre, N. Teixido, J. Usall, and I. Vinas, Effect of freeze drying 369, 2001.

B. R. Bhandari and T. Howes, Implication of glass transition for the drying and stability of dried foods, Journal of Food Engineering, vol.40, issue.1-2, pp.71-79, 1999.
DOI : 10.1016/S0260-8774(99)00039-4

A. D. Breen, J. G. Curley, D. E. Overcashier, C. C. Hsu, and S. J. Shire, Effect of 374 moisture on the stability of a lyophilized humanized monoclonal antibody formulation, p.375, 2001.

M. P. Buera and M. Karel, Effect of physical changes on the rates of nonenzymic browning and related reactions, Food Chemistry, vol.52, issue.2, pp.167-173, 1995.
DOI : 10.1016/0308-8146(94)P4199-P

P. Buera, C. Schebor, and B. Elizalde, Effects of carbohydrate crystallization on 379 stability of dehydrated foods and ingredient formulations, Journal of Food Engineering, vol.67, pp.380-381, 2005.

J. F. Carpenter and J. H. Crowe, An infrared spectroscopic study of the interactions of carbohydrates with dried proteins, Biochemistry, vol.28, issue.9, pp.3916-3922, 1989.
DOI : 10.1021/bi00435a044

A. S. Carvalho, J. Silva, P. Ho, P. Teixeira, F. X. Malcata et al., Relevant 384 factors for the preparation of freeze-dried lactic acid bacteria, International Dairy Journal, vol.14, issue.10, pp.385-835, 2004.

H. P. Castro, P. M. Teixeira, and R. Kirby, Evidence of membrane damage in 387, 1997.

C. P. Champagne, N. Gardner, E. Brochu, and Y. Beaulieu, The freeze-drying of 390, 1991.

L. Q. Chang, D. Shepherd, J. Sun, X. L. Tang, and M. J. Pikal, Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state, Journal of Pharmaceutical Sciences, vol.94, issue.7, pp.1445-1455, 2005.
DOI : 10.1002/jps.20363

P. B. Conrad, D. P. Miller, P. R. Cielenski, and J. J. De-pablo, Stabilization and 401 preservation of Lactobacillus acidophilus in saccharide matrices, Cryobiology, vol.1, pp.41-58, 2000.

G. Corrieu, H. E. Spinnler, D. Picque, and Y. Jomier, Automated system to follow up 403 and control the acidification activity of lactic acid starters, 1988.

H. R. Costantino, J. G. Curley, and C. C. Hsu, Determining the water sorption 406, 1997.

H. R. Costantino, J. G. Curley, S. Wu, and C. C. Hsu, Water sorption behavior of 409 lyophilized protein-sugar systems and implications for solid-state interactions, 1998.

J. H. Crowe, J. F. Carpenter, and L. M. Crowe, THE ROLE OF VITRIFICATION IN ANHYDROBIOSIS, Annual Review of Physiology, vol.60, issue.1, pp.73-103, 1998.
DOI : 10.1146/annurev.physiol.60.1.73

M. Croyle, X. Cheng, and J. Wilson, Development of formulations that enhance physical stability of viral vectors for gene therapy, Gene Therapy, vol.8, issue.17, pp.1281-1290, 2001.
DOI : 10.1038/sj.gt.3301527

F. Fonseca, C. Beal, and G. Corrieu, Method of quantifying the loss of acidification 421 activity of lactic acid starters during freezing and frozen storage, Journal of Dairy Research, vol.422, pp.67-83, 2000.

F. Fonseca, J. P. Obert, C. Béal, and M. Marin, State diagrams and sorption isotherms of bacterial suspensions and fermented medium, Thermochimica Acta, vol.366, issue.2, pp.167-182, 2001.
DOI : 10.1016/S0040-6031(00)00725-5

D. Greiff, Stabilities of suspensions of influenza virus dried by sublimation of ice in 426, 1970.

M. J. Hageman, Water sorption and solid-state stability of proteins, p.429, 1992.

B. Higl, L. Kurtmann, C. U. Carlsen, J. Ratjen, and P. Först, Impact of Water Activity, Temperature, and Physical State on the Storage Stability of Lactobacillus paracasei ssp. paracasei Freeze-Dried in a Lactose Matrix, Biotechnology Progress, vol.23, issue.4, pp.794-800, 2007.
DOI : 10.1021/bp070089d

K. Jouppila and Y. H. Roos, Glass Transitions and Crystallization in Milk Powders, Journal of Dairy Science, vol.77, issue.10, p.438, 1994.
DOI : 10.3168/jds.S0022-0302(94)77231-3

K. Jouppila and Y. H. Roos, Water Sorption and Time-Dependent Phenomena of Milk Powders, Journal of Dairy Science, vol.77, issue.7, pp.1798-1808, 1994.
DOI : 10.3168/jds.S0022-0302(94)77121-6

R. Karmas, M. P. Buera, and M. Karel, Effect of glass transition on rates of 444 nonenzymatic browning in food systems, Journal of Agricultural and Food Chemistry, vol.40, pp.445-873, 1992.

L. Kurtmann, C. U. Carlsen, J. Risbo, and L. H. Skibsted, Storage stability of freeze, p.447, 2009.

T. Labuza, The effect of water activity on reaction kinetics of food deterioration. 453 Food Technology, pp.36-41, 1980.

M. C. Lai and E. M. Topp, Solid?state chemical stability of proteins and peptides, Journal of Pharmaceutical Sciences, vol.88, issue.5, p.455, 1999.
DOI : 10.1021/js980374e

D. Lechuga-ballesteros, D. P. Miller, and J. Zhang, Residual water in amorphous 457 solids: Measurements and effects on stability, Progress in Amorphous 458, 2002.
DOI : 10.1039/9781847550118-00275

S. M. Lievonen, T. J. Laaksonen, and Y. H. Roos, Glass Transition and Reaction Rates:? Nonenzymatic Browning in Glassy and Liquid Systems, Journal of Agricultural and Food Chemistry, vol.46, issue.7, p.464, 1998.
DOI : 10.1021/jf980064h

C. Santivarangkna, B. Higl, and P. Foerst, Protection mechanisms of sugars during 517 different stages of preparation process of dried lactic acid starter cultures, Food Microbiology, vol.518, pp.25-429, 2008.

C. Schebor, M. P. Buera, M. Karel, and J. Chirife, Color formation due to non- 520 enzymatic browning in amorphous, glassy, anhydrous, model systems, Food Chemistry, vol.65, issue.65, pp.521-427, 1999.
DOI : 10.1016/s0308-8146(98)00041-7

A. Schoug, D. Mahlin, M. Jonson, and S. Hakansson, Si3 freeze-dried in sucrose, Journal of Applied Microbiology, vol.41, issue.3, pp.1032-1040, 2010.
DOI : 10.1111/j.1365-2672.2009.04506.x

W. J. Scott, The Effect of Residual Water on the Survival of Dried Bacteria During Storage, Journal of General Microbiology, vol.19, issue.3, pp.624-633, 1958.
DOI : 10.1099/00221287-19-3-624

L. Slade and H. Levine, Beyong water activity: recent advances based on an 531 alternative approach to the assessment of food quality and food safety, Critical Review, p.532, 1991.

F. Streit, G. Corrieu, and C. Beal, Acidification improves cryotolerance of 534, 2007.

W. Q. Sun and P. Davidson, Protein inactivation in amorphous sucrose and trehalose 536 matrices : Effects of phase separation and crystallization, Biochimica et Biophysica Acta, vol.537, pp.1425-235, 1998.

P. Teixeira, H. Castro, and R. Kirby, Evidence of membrane lipid oxidation of spray, p.539, 1996.

C. D. Teng, M. H. Zarrintan, and M. J. Groves, Water vapor adsorption and desorption 544 isotherms of biologically active proteins, Pharmaceutical Research, vol.08, issue.2, pp.191-195, 1991.
DOI : 10.1023/A:1015835902721

G. Vuataz, Article, Le Lait, vol.82, issue.4, pp.485-500, 2002.
DOI : 10.1051/lait:2002026

J. X. Yu and T. J. Anchordoquy, Effects of Moisture Content on the Storage Stability of Dried Lipoplex Formulations, Journal of Pharmaceutical Sciences, vol.98, issue.9, pp.3278-3289, 2009.
DOI : 10.1002/jps.21846

G. Zayed and Y. H. Roos, Influence of trehalose and moisture content on survival of 549, 2004.

J. Zhang and G. Zografi, The relationship between "BET" and "free volume"-derived 552 parameters for water vapor absorption into amorphous solids, Journal of Pharmaceutical, vol.553, 2000.

G. Zhao and G. Zhang, Effect of protective agents, freezing temperature, rehydration 555 media on viability of malolactic bacteria subjected to freeze-drying, Journal of Applied, vol.556, 2005.