Organic Nanoscrolls from Electrostatic Interactions between Peptides and Lipids: Assembly Steps and Structure

Abstract : An important aspect of cells is their shape flexibility that gives them motion but also a high adaptation versatility to their environment. This shape versatility is mediated by different types of protein−membrane interactions among which electrostatic plays an important role. In the present work we examined the interaction between a small dicationic peptide, that possesses self-assembly properties, and lipid model membranes. The peptide, lanreotide, spontaneously forms nanotubes in water that have a strictly uniform diameter. In the current work, we show that the interaction between the cationic peptide and negatively charged bilayers of lipids induces the formation of myelin sheath-like structures that we call nanoscrolls. By deciphering the different steps of formation and the molecular structure of the self-assembly, we show how electrostatics modify the spontaneous peptide and lipid way of packing.
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Soumis le : lundi 26 août 2019 - 10:53:45
Dernière modification le : vendredi 30 août 2019 - 01:09:30

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Pierre Chervy, Cristina Petcut, Damien Rault, Cristelle Mériadec, Thomas Bizien, et al.. Organic Nanoscrolls from Electrostatic Interactions between Peptides and Lipids: Assembly Steps and Structure. Langmuir, American Chemical Society, 2019, 35 (32), pp.10648-10657. ⟨10.1021/acs.langmuir.9b01542⟩. ⟨hal-02270661⟩

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