Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis

Alain Garcia de Las Bayonas (1) , Jean-Marc Philippe (2) , Annemarie Lellouch (1) , Thomas Lecuit (3)

1 IBDM - Institut de Biologie du Développement de Marseille
2 NBCM - Laboratoire de neurobiologie cellulaire et moléculaire
3 Collège de France - Chaire Dynamiques du vivant

Graphical Abstract Highlights d Dp114RhoGEF activates junctional Rho1 and is involved in cell intercalation d Ga/Cta and Gbg subunits tune, respectively, RhoGEF2 and Dp114RhoGEF membrane levels d Gbg subunits control planar polarity of junctional Rho1 signaling via Dp114RhoGEF d Tissue-specific RhoGEFs could diversify morphogenesis in different tissues

Domaines: Sciences du Vivant [q-bio]

Alain Garcia de Las Bayonas, Jean-Marc Philippe, Annemarie Lellouch, Thomas Lecuit. Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis. Current Biology - CB, 2019, 29 (20), pp.3370-3385.e7. ⟨10.1016/j.cub.2019.08.017⟩. ⟨hal-02369615⟩